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Method for the separation of S-(−)-amlodipine from racemic amlodipine
Method for the separation of S-(−)-amlodipine from racemic amlodipine
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机译:从外消旋氨氯地平中分离S-(-)-氨氯地平的方法
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摘要
Disclosed is a method for the separation of S-(−)-amlodipine from a racemic amlodipine. Featuring the use of inexpensive L-tartaric acid as an optical resolution agent and DMAC as a solvent, the separation method allows the resolution of S-(−)-amlodipine from racemic amlodipine at high yield and to a satisfactory enantiomeric excess and thus is economically favorable and applicable to the mass production of the optical isomer.
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