MicroRNA (miRNA) as a Biomarker for the identification of familial and nonfamilial colorectal cancer

摘要

Claim 1: a method for Diagnosing colorectal cancer (CRC) in a Human subject, which comprises the following steps: identify a subject suspected of Suffering from CRC; to obtain one or more biological samples of the subject, where biological samples selected from the gr Upo is a Tissue Sample, a stool SampleA cell homogenate and one or more Biological Fluids, including Blood, lymph, plasma, urine, cerebrospinal fluid, amniotic fluid, pus, and Tears; determine the patterns of expression of one or more types of microRNA (miRNA) in biological samples by The use of a microarray,Where one or more types of microRNA are regulated positively or negatively regulated in a Tissue sample from the subject suspected of Suffering from CRC; and compare the pattern of expression of Mirna in the Biological sample from the subject suspected of PADE EC a CRC with the pattern of expression of Mirna in a tissue of a normal subject,Where the normal subject is a Subject that does not have a Healthy crc.reivindicaciu00f3n 6: the method of claim 1 wherein the CRC covers the Lynch Syndrome, tumors with level of microsatellite instability (MSI) and sporadic tumors with microsatellite Stable (MSS).