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pharmaceutical production for contraception and risk reduction of congenital malformations
pharmaceutical production for contraception and risk reduction of congenital malformations
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机译:用于避孕和降低先天性畸形风险的药物生产
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摘要
PHARMACEUTICAL PRODUCTION FOR CONTRACEPTION AND RISK REDUCTION OF CONGENITAL MALFORMATION. The present invention relates to a pharmaceutical preparation for contraception containing in a daily dose -2.0 mg or 1.5 mg of 17α-cyanomethyl-17-B-hydroxystra-4,9-dien-3-one (dienogest) and 0.015 mg 17α-ethynyl estradiol (ethinyl estradiol) and (6S) -5-methyl tetrahydrofolate, preferably as (6S) -5-methyl tetrahydrofolic acid (metapholine) calcium salt together with one or more pharmaceutically acceptable co-adjuvants or vehicles . The pharmaceutical preparation according to the invention performs both oral contraception and a means for minimizing the risk of congenital malformations. In addition, a kit contains 21 daily unit doses of the pharmaceutical preparation, and 7 daily unit doses containing only (6S) -5-methyl tetrahydrofolate, also preferably metapholine.
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