COMPOUND, PHARMACEUTICAL COMPOSITION, PACKAGED PHARMACEUTICAL COMPOSITION AND ITS USES, METHOD FOR TREATING A PATIENT SUFFERING FROM A DISEASE RESPONSIBLE FOR BTK ACTIVITY OR DISEASES, ALAN DISORDERS, CHILD DISEASES, METHOD FOR REDUCING MEDICATION ERROR AND IMPROVING THERAPEUTIC COMPLIANCE WITH A PATIENT DISEASE RESPONSE AND METHODS TO INHIBIT ATP HYDROLYSIS, TO DETERMINE INTENSE TO A PRESENCE BE CELL ACTIVITY TO INCREASE SENSITIVITY OF CANCERYGEN CELLS TO CHEMOTHERAPY.

摘要

At least one chemical entity chosen from compounds of Formula 1 and pharmaceutically acceptable salts, solvates, chelates, non-covalent complexes, prodrugs, and mixtures thereof is described herein. Pharmaceutical compositions comprising at least one chemical entity of the invention, together with at least one pharmaceutically acceptable vehicle chosen from carriers adjuvants, and excipients, are described. Methods of treating patients suffering from certain diseases responsive to inhibition of Btk activity and/or B-cell activity are described. Methods for determining the presence of Btk in a sample are described.