Process for preparing Naltrexone comprising reacting with ciclopropilmetil noroximorfona Halide in the presence of N - ethyl - 2 - pyrrolidone; Manufacturing process to prepare nalmafeno comprising nAltrexona and process in addition to nalmafeno from through Wittig reaction; Naltrexone; and nalmafeno.

摘要

The present invention relates to an improved process for producing naltrexone [17-(cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-morphinan-6-one] from noroxymorphone [4,5-alpha-epoxy-3,14-dihydroxy-morphinan-6-one] by alkylation with a cyclopropylmethyl halide.