Mammalian expression vector for chinese hamster ovary (cho) host cells, cho cells comprising the same and process for improving the level of production of a secreted molecule

摘要

The invention relates to a mammalian host cell with a high-level expression of recombinant antibody containing a double-gene vector with gene optimized nucleotide sequences encoding the light and the heavy antibody chains, the double-gene vector itself and a process for enhancing the production of recombinant antibody in a mammalian host cell.