MICROWAVE ASSISTED SYNTHESIS OF 4-TERTBUTYLCALIXNARENES HAVING PHENYL SUBSTITUENTS ON METHYLENE BRIDGES IN PRESENCE OF ALUMINA SUPPORTED KF UNDER SOLVENT FREE CONDITIONS.

摘要

The present invention relates to a novel process for preparing 2,8,14,20,26,32,38,44- octa phenyl - 5,11,17,23,29,35,41,47- octa-tert butyl 49,50,51,52,53,54,55,56- octahydroxycalix [8]arene (XXXI); 2,8,14,20,26,32-hexa(4-chloro)phenyl-5,l 1,17,23,29, 35 -hexa-tertbuty 1-37,38,39,40,41,42- hexahydroxycalix[6]arene ( XXXII ); 2,8,14,20,26,32-hexa(3-chloro)phenyl-5,11,17,23,29, 35 -hexa- tertbutyl-37,38,39,40,41,42-hexahydroxycalix[6]arene ( XXXIII ); 2,8,14,20,26,32,38,44,50- nona (4- bromo) phenyl-5,11,17,23,29,35,41,47,53- nona-tertbutyl- 55,56,57,58,59,60,61, 62, 63- nonahydroxycalix [9] arene ( XXXIV ); 2,8,14,20,26,32,38,44- octa (4-fluoro) phenyl - 5,11 17,23,29,35,41,47- octa-tertbutyl 49,50,51,52,53,54,55,56- octahydroxycalix [8]arene ( XXXV ); 2,8,14,20,26,32,38,44,50,56-deca (4-nitro) phenyl-5,11,17,23,29,35,41,47,53,59-deca-tertbutyI- 61,62,63,64,65,66,67, 68, 69,70- decahydroxycalix [10] arene ( XXXVI); 2,8,14,20,26,32,38,44,50,56,-deca (3-nitro) phenyl- 5,11,17,23,29,35, 41,47,53,59-deca-tertbutyl- 61,62,63,64,65,66, 67, 68, 69,70-decahydroxycalix [10] arene (XXXVII ); 2,8,14,20,26,32,38,44,50,56,- deca (2-nitro) phenyl-5,11,17,23,29,35,41,47,53,59-deca-tertbutyl- 61,62,63,64,65,66, 67, 68, 69,70- decahydroxycalix [10] arene (XXXVIO ); 2, 8, 14, 20,26,32,38,44,50,56-deca (4-cyano) phenyl-5,11,17,23,29,35,41,47,53,59-deca-tertbutyl-61,62,63,64,65,66,67, 68, 69,70- decahydroxycalix [10] arene (XXXIX); 2,8,14,20,26,32,38,44- octa (4-methoxy) phenyl -5,11„17,23,29,35,41,47- octa-tertbutyl 49,50,51,52,53,54,55,56- octahydroxycalix [8]arene ( XL); 2,8,14,20,26,32,38,44- octa (3-methoxy) phenyl -5,11 „ 17,23,29,35,41,47- octa-tertbutyl 49,50,51,52,53,54,55,56- octahydroxycalix [8]arene (XLI ); 2,8,14,20,26,32-hexa(3,4-dimethoxy)phenyl-5,l 1,17,23,295,-trimethoxy) phenyl - 5,11,17,23 tetra-tertbutyl 25,26,27,28- tetrahydroxycalix [4] arene (XL, 35 -hexa-tertbutyl-37,38,39,40,41,42-hexahydroxyca!ix[6]arene (XLII); 2,8,14,20- tetra (3,4,III); 2,8,14,20- tetra (2,4,6,- trimethoxy) phenyl -5,11,17,23 tetra-tertbutyl 25,26,27,28- tetrahydroxycalix [4] arene (XLIV):- 2,8,14,20- tetra (4-dimethylamino) phenyl - 5,11,17,23 tetra-tertbutyl 25,26,27,28- tetrahydroxycalix [4] arene (XLV) in presence of alumina supported KF under microwave irradiation and solvent free conditions.