CHRONOMODULATED SOLID DOSAGE FORM CONTAINING A COMBINATION OF ANTIHYPERTENSIVE, ANTIDIABETIC AND ANTIHYPERLIPIDEMIC DRUGS

摘要

Co-occurrence of diabetes, hypertension and hyperlipidemia is quite common. In such case a patient has to consume several tablets in a day. Regimen may include two to three tablet three to four times a day. The most cumbersome part in such therapy becomes management of early morning hypertension and variable level of blood lipid level by the virtue of circadian rhythm. This invention chronomodulates the drug delivery in such a manner that maximum concentration is attained when required. Formulation is meant for bed time dosing. Verapamil hydrochloride is modulated to prevent early morning hypertension, gliclazide to attain maximum concentration before breakfast and simvastatin between 12:00 to 2:00 pm. Such chronomodulated tablet is formulated by compression coating technique. After administration the formulation shows an initial slow and/or nil release of the drugs. Attaining of approximately 50 to 75% of label claim of the verapamil hydrochloride after 10-11 hrs, 50 to 75% of label claim of gliclazide after 12-13 hrs and NLT 85% of label claim of simvastatin after 16 to 18 hrs of oral consumption of the tablet makes it suitable for once daily administration.