p-mTOR and p-AKT as Ratio Based Biomarkers for the Prognosis and/or Diagnosis of Cancer

摘要

593514 Disclosed is a method of determining cancer prognosis or the presence of cancer, comprising: Identifying at least two cancer associated proteins in a sample from the subject, wherein the at least two cancer associated proteins comprise p-mTOR and p-AKT; Quantifying the at least two cancer associated proteins in the sample; Normalising the at least two cancer associated proteins in the sample to obtain a normalised value for each cancer associated protein in the sample; Comparing the normalised value of the first cancer associated protein with the normalised value of the second cancer associated protein to obtain a biomarker indicator that comprises a ratio of the normalised value of the first cancer associated protein to the normalised value of the second cancer associated protein; and Correlating the biomarker indicator with prognosis of the subject with cancer.