derivatives of aza spiro - 2 nonane - carboxylates, their preparation and their application in thepapeutique

摘要

The compound conforms to the general formula ((I), wherein R2 represents hydrogen, fluorine or hydroxyl, cyano, trifluoromethyl, ci-6-alkyl, c1-6-alcoxy, nr8r9, m, N, O and P independently represent 0-3; but M + n or equal to 7 and O + or a. It is covalent bond, oxygen atom, c1-6-alkylen group or o-c1-6-alkylen group, where the end represented by oxygen atom is connected with R1 group, and the end represented by alkyl group is connected with bicycle carbon;R1 represents an optional substituted aryl or heteroaryl group;R3 represents hydrogen atom, fluorine atom, c1-6-alkyl or trifluoromethyl; R4 represents five heterocycles of any selected generation chain;Alkali or acid addition salt. The invention can be used for treatment.