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COMPUTATION OF THE COMBINED POTENCY OF DRUG REGIMENS FROM FITTED OR IN VITRO DETERMINED DOSE-RESPONSE CURVES
COMPUTATION OF THE COMBINED POTENCY OF DRUG REGIMENS FROM FITTED OR IN VITRO DETERMINED DOSE-RESPONSE CURVES
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机译:用拟合或体外测定的剂量反应曲线计算药物方案的总效价
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摘要
A method is described that computes the combined potency of a drug regimen based on predicted or in vitro determined dose-response response curves of the individual drugs in a treatment regimen. This is instrumental in those diagnostic situations where different instances of biomolecule sequences or other biomarkers are associated with a different, but measurable or predictable shape of the dose-response curve of one or more of the regimen drugs, and where the response to the drug can be translated to a (surrogate) clinical endpoint.
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