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OSTEOARTHRITIS MODEL ANIMAL FOR ESTABLISHING A SPONTANEOUS OSTEOARTHRITIS MODEL WHICH IS NEAR TO HUMAN OSTEOARTHRITIS WITHIN RODENTS
OSTEOARTHRITIS MODEL ANIMAL FOR ESTABLISHING A SPONTANEOUS OSTEOARTHRITIS MODEL WHICH IS NEAR TO HUMAN OSTEOARTHRITIS WITHIN RODENTS
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机译:用于建立自律性骨关节炎的自发性骨关节炎模型的动物骨关节炎模型
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摘要
PURPOSE: An osteoarthritis model animal is provided to easily get an animal with limited breeding space and induce similar human osteoarthritis without controlling chemical substances or surgical manipulations.;CONSTITUTION: A manufacturing method of an osteoarthritis model animal comprises a step of inducing obesity to rodent animal with high fat diet for at least eight weeks; a step of putting on a track belt which lets the rodent animal be induced with obesity rotates magnetic track belt and a miniature treadmill of rodent equipped with a driving unit which drives track be a step of connecting and fixing the upper part of body to a rod of fixing the upper body; a step of exercising an upright-walking of the rodent animal which moves the left leg and right leg by turns; a step of exercising an upright-walking after inducing obesity for one hour a week on a treadmill; a step of maintaining exercise for 3-5 weeks which started from the second week for two hours a day in case of no weight loss noted over 5%; a step of inducing osteoarthritis by exercising an upright-walking for three hours a day in a treadmill in case of no weight loss noted over 5%.;COPYRIGHT KIPO 2013
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