PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING RENAL ISCHEMIA REPERFUSION INJURY COMPRISING CD137 OR CD137 LIGAND INHIBITOR AS ACTIVE INGREDIENTS

摘要

PURPOSE: A pharmaceutical composition for preventing or treating renal ischemia reperfusion injury is provided to function as the target of a diagnosing or treating medicine for renal ischemia reperfusion injury. CONSTITUTION: A pharmaceutical composition for diagnosing renal ischemia reperfusion injury comprises a probe or a primer having a complementary sequence with respect to the nucleotide sequence of a CD137 gene or a CD137 ligand. The CD137 gene is expressed on the natural killer cells of a kidney, and the CD137 ligand is expressed on the epithelial cell of the kidney. A screening method of a material for preventing or treating renal ischemia reperfusion injury comprises the steps of: contacting a specimen to be analyzed with a cell comprising a CD137 gene, a CD137 ligand, and a CD137 protein; measuring the expressed amount of the CD137 gene or the CD137 ligand, the amount of the CD137 protein, or the activity of the CD137 protein; and verifying the specimen as the material for preventing or treating renal ischemia reperfusion injury from the measured activity reduction.