Apoptosis-inducing agents for the treatment of malignant tumors and immune and autoimmune diseases

摘要

1. The compound of formula (I) or a therapeutically acceptable salt thereof, wherein A is N or C (A); A is H, R, OR, SR, S (O) R, SOR, C (O) R, C (O) OR, OC (O) R, NHR, N (R), C (O) NHR, C (O) N (R), NHC (O) R, NRC (O) R, NHC (O) OR, NRC ( O) OR, NHC (O) NH, NHC (O) NHR, NHC (O) N (R), NRC (O) NHR, NRC (O) N (R), SONH, SONHR, SON (R), NHSOR , NRSOR, NHSONHR, NHSON (R), NRSONHR, NRSON (R), C (O) NHNOH, C (O) NHNOR, C (O) NHSOR, C (NH) NH, C (NH) NHR, C (NH ) N (R), NHSONHR, NHSON (CH) R, N (CH) SON (CH) R, F, Cl, Br, I, CN, NO, N, OH, C (O) H, CHNOH, CH ( NOCH), CF, C (O) OH, C (O) NH or C (O) OR; B is H, R, OR, SR, S (O) R, SOR, C (O) R, C (O) OR, OC (O) R, NHR, N (R), C (O) NHR, C (O) N (R), NHC (O) R, NRC (O) R, NHC (O) OR, NRC ( O) OR, NHC (O) NH, NHC (O) NHR, NHC (O) N (R), NRC (O) NHR, NRC (O) N (R), SONH, SONHR, SON (R), NHSOR , NRSOR, NHSONHR, NHSON (R), NRSONHR, NRSON (R), C (O) NHNOH, C (O) NHNOR, C (O) NHSOR, C (NH) NH, C (NH) NHR, C (NH ) N (R), NHSONHR, NHSON (CH) R, N (CH) SON (CH) R, F, Cl, Br, I, CN, NO, N, OH, C (O) H, CHNOH, CH (NOCH), CF, C (O) OH, C (O) NH or C (O) OR; D is H, R, OR, SR, S (O) R, SOR, C (O) R, C (O) OR, OC (O) R, NHR , N (R), C (O) NHR, C (O) N (R), NHC (O) R, NRC (O) R, NHC (O) OR, NRC (O) OR, NHC (O) NH , NHC (O) NHR, NHC (O) N (R), NRC (O) NHR, NRC (O) N (R), SONH, SONHR, SON (R), NHSOR, NRSOR, NHSONHR, NHSON (R) , NRSONHR, NRSON (R), C (O) NHNOH, C (O) NHNOR, C (O) NHSOR, C (NH) NH, C (NH) NHR, C (NH) N (R), NHSONHR, NHSON (CH) R, N (CH) SON (CH) R, F, Cl, Br, I, CN, NO, N, OH, C (O) H, CHNOH, CH (NOCH), CF, C (O) OH, C (O) NH or C (O) OR; E is H, R, OR, SR, S (O) R, SOR, C (O) R, C (O) OR, OC (O) R, NHR , N (R), C (O) NHR, C (O) N (R), NHC (O) R, NRC (O) R, NHC (O) OR, NRC (O) OR, NHC (O) NH , NHC (O) NHR, NHC (O) N (R), NRC (O) NHR, NRC (O) N (R), SONH, SONHR, SON (R), NHSOR, NRSOR, NHSONHR, NHSON (R) , NRSONHR, NRSON (R), C (O) NHNOH, C (O) NHNOR, C (O) NHSOR, C (NH) NH, C (NH) NHR, C (NH) N (R), NHSONHR, NHSON (CH) R, N (CH) SON (CH) R, F, Cl, Br, I, CN, NO, N, OH, C (O) H, CHNOH, C H (NOCH), CF, C (O) OH, C (O) NH or C (O) OR; and Y is H, CN, NO, C (O) OH, F, Cl, Br, I, CF, OCF, CFCF, OCFCF, R, OR, C (O) R, C (O) OR, SR, SOR, NH, NHR, N (R), NHC (O) R, C (O) NH, C (O) NHR, C (O) N (R), NHS (O) R or NHSOR; or E and Y, together with the atoms to which they are attached, are benzene, naphthylene, heteroarene, cycloalkane, cycloalkene, heterocycloalkane or heterocycloalkene; and A, B, and D are independently selected from H, R, OR, SR, S (O) R, SOR, C (O) R, C (O) OR, OC (O) R, NHR, N (R), C (O ) NHR, C (O) N (R), NHC (O) R, NRC (O) R, NHC (O) OR, NRC (O) OR, NHC (O) NH, NHC (O) NHR, NHC ( O) N (R), NRC (O) NHR, NRC (O) N (R), SONH, SONHR, SON (R), NHSOR, NRSOR, NHSONHR, NHSON (R), NRSONHR, NRSON (R), C (O) NHNOH, C (O) NHNOR, C (O) NHSOR, C (NH) NH, C (NH) NHR, C (NH) N (R), NHSONHR, NHSON (CH) R, N (CH) SON (CH) R, F, Cl, Br, I, CN, NO, N, OH, C (O) H, CHNOH, CH (NOCH), CF, C (O)