METHOD FOR PREPARING BIOLOGICALLY ACTIVE NANOLIQUID OF FERRIC OXIDE (II, III) NANOPARTICLES AND 3-HYDROXY PYRIDINE DERIVATIVE

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention refers to chemical-pharmaceutical industry and represents a method for preparing a biologically active disperse system representing a nanoliquid of ferric oxide (II, III) nanoparticles. The method differs by preparing 3-6% low-molecular polyvinyl pyrrolidone 8000±2000 wherein a solvent represents a liquid containing sodium chloride 2.75-5.5 g, potassium chloride 0.21-0.42 g, calcium chloride 0.25-0.5 g, magnesium chloride 0.00025-0.005 g, sodium bicarbonate 0.115-0.23 g and distilled water up to 1 l; the prepared solution is delivered to a mixture of powdered ferric oxide (II, III) USPIO nanoparticles of 5-8 nm deposited on sodium chloride crystals taken at 1-10 mg per one ml of the disperse system, and a substance of 3-hydroxypyridine derivative taken at 1-200 mg per one ml of the disperse system; it is thoroughly mixed and kept at +60°C throughout 2 hours; the prepared liquid is gradually cooled to room temperature (+20°C) followed by sediment detachment.;EFFECT: invention provides one-stage preparation of the nanoliquid with no toxic reagents, and nanoliquid stability; the composite nanoparticle size therein and biological activity of the ingredients provides advanced biomedical application thereof.;3 cl, 4 dwg, 3 ex, 7 tbl