SYSTEMS AND METHODS FOR IDENTIFYING A CONTRIBUTOR'S STR GENOTYPE BASED ON A DNA SAMPLE HAVING MULTIPLE CONTRIBUTORS

摘要

Under one aspect of the present invention, a method is provided for analyzing a mixture of DNA from two or more contributors, to identify at least one contributor's STR genotypes at a plurality of STR loci. Possible solutions may be determined independently for each STR locus, each solution including the number of contributors, an STR genotype for each contributor at that locus, an abundance ratio of their respective contributions, and a confidence score. The most likely solutions for the STR locus having the highest confidence score then are used as givens, based upon which the solutions for the other STR loci may be sequentially obtained, in each instance using as givens the most likely solutions for any previously analyzed loci. STR genotypes are output that share as givens the number of contributors and the abundance ratio used in the most likely solution for the last analyzed STR locus.