Actin cytoskeletal rearrangement and method of regulation of intercellular gap formation

摘要

Methods are described for reducing cytoskeletal rearrangement and intercellular gap formation by contacting cells with an aminoalkyl glucosaminide phosphate. In particular, the methods can be used to reduce actin cytoskeletal rearrangement and/or intracellular gap formation related to ischemic or ischemia-reperfusion events and to alleviate diseases or conditions related to increased actin cytoskeletal rearrangement.