首页>
外国专利>
Method for Improving the Stability of Purified Factor VIII After Reconstitution
Method for Improving the Stability of Purified Factor VIII After Reconstitution
展开▼
机译:重组后提高纯化的凝血因子ability稳定性的方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to a method for increasing the stability of a Factor VIII molecule after purification, lyophilization and reconstitution, comprising preventing proteolytic cleavage of the Factor VIII molecule into a first fragment comprising essentially the A1 domain and the A2 domain and a second fragment comprising essentially the A3 domain, the C1 domain and the C2 domain throughout manufacturing of the Factor VIII molecule. The invention further pertains to a method for improving the bioavailability of Factor VIII after intravenous and non-intravenous injection.
展开▼