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Live attenuated bacterial vaccine to reduce or inhibit carriage and shedding of enterohemorrhagic Escherichia coli in cattle

机译：减毒活细菌疫苗，以减少或抑制牛肠出血性大肠埃希氏菌的携带和脱落

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摘要

The invention provides live, attenuated enterohemorrhagic Escherichia coli (EHEC) bacteria in which the Shiga toxin coding sequences are deleted to abolish Shiga toxin production and one or more of the nucleotide sequences for the bacterial adhesin protein intimin, the locus of enterocyte effacement encoded regulator, and the translocated intimin receptor are mutated to inactivate the activity of the encoded protein(s). This live, attenuated E. coli bacteria is used in a vaccine for reducing or inhibiting carriage and shedding of EHEC in cattle.

机译：本发明提供了活的，减毒的肠出血性大肠杆菌（EHEC）细菌，其中删除了志贺毒素编码序列以消除志贺毒素的产生，以及细菌粘附素蛋白内膜素的一个或多个核苷酸序列，即肠细胞表面受损编码调控子的基因座和易位的intimin受体发生突变，使编码蛋白的活性失活。此带电的衰减后的 E。大肠杆菌用于减少或抑制牛体内EHEC的运输和脱落。 展开▼

著录项

公开/公告号US8858930B2

专利类型

公开/公告日2014-10-14

原文格式PDF

申请/专利权人 CHENGRU ZHU;EDGAR BOEDEKER;
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申请/专利号US20050666251

发明设计人 CHENGRU ZHU;EDGAR BOEDEKER;
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申请日2005-10-26

分类号A01N63;A61K39/108;A61K39/02;C07K14/245;C12N1/36;A61K39;

国家 US

入库时间 2022-08-21 16:06:29

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