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Cells and Vertebrates for Enhanced Somatic Hypermutation and Class Switch Recombination
Cells and Vertebrates for Enhanced Somatic Hypermutation and Class Switch Recombination
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机译:细胞和脊椎动物增强体细胞超突变和类开关重组
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摘要
The invention provides improved non-human vertebrates and non-vertebrate cells capable of expressing antibodies, eg, comprising human variable region sequences. The invention provides for enhanced AID and/or AID homologue spectra, thereby providing for the increased diversity as a result of somatic hypermutation and/or class-switch recombination during in vivo antibody generation. The invention also provides methods of generating antibodies using such vertebrates, as well as the antibodies per se, therapeutic compositions thereof and uses.
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