PROCESS FOR PREPARATION OF MEGLUMINE ANTIMONIATE AND POTASSIUM ANTIMONIATE USED IN PROTOZOONOSES TREATMENT

摘要

Process for the preparation of antimu00c8nico acid derivatives used in the treatment of protozoonoses.The present invention relates to a new and simple procedure for the synthesis of derivatives of antimonic acid to be used in the treatment of canine leishmaniasis and human and applied to other.Nfermidades in the drugs in question show activity. This invention is a new route for the preparation of antimoniato of meglumine and other derivatives of antimonic acid.The new procedure for the synthesis of derivatives of antimonic acid follows the route: 1.Synthesis of antimoniato of meglumine: (a) the hydrolysis of antimony pentachloride SbCl ~ 5 ~ with water to obtain the antimonic acid is separated by centrifugation.(b) reaction of the antimonic acid thus obtained with N - methyl - glucamina in quantities estequiometricas in aqueous medium and potassium hydroxide at a temperature between 40 to 90 u00b0 C.The product is precipitated in acetone and separated by decantation. Is that the antimoniato of meglumine molecular formula: C ~ 7 ~ H ~ 18 ~ ~ ~ ~ 2 ~ the sb.3h 8