COMPOSITION, METHODS FOR ADENOSINE A1 RECEPTOR MODULATION AND FOR THE TREATMENT OF CONDITIONS MEDIATED BY ADENOSINE A1 RECEIVER IN MAMMALS, PHARMACEUTICAL COMPOSITION, AND USES OF A COMPOSITION AND A COMPOUND

摘要

The present invention provides compounds of formula (I) wherein RSUB1/SUB, RSUB2/SUB, RSUB3/SUB, RSUB4/SUB and Q have a meaning as defined herein in the specification. The compounds of formula (I) are allosteric modulators of the ASUB1/SUB adenosine receptor and, thus, may be employed for the treatment of conditions mediated by the ASUB1/SUB adenosine receptor. Accordingly, the compounds of formula (I) may be employed for treatment of pain, in particular, chronic pain such as neuropathic pain; cardiac disease or disorder such as cardiac disarrhythmias, e.g., peroxysmal supraventricular tachycardia, angina, myocardial infarction and stroke; neurological disease or injury; sleep disorder; epilepsy; and depression.