A training image, pharmaceutical composition, and kit for the preparation of the same, in conjunction, cianina dye, and methods of training in vivo optical image of the body of a mammalian and detection, assessment of stage, diagnosis, monitorau00c7u00c3o of radiographic of disease the U monitorau00c7u00c3o treatment of sickness of the body of a mammalian

摘要

The present invention relates to imaging agents suitable for in vivo optical imaging, which comprise conjugates of pentamethine cyanine dyes having reduced non-specific binding, e.g. to plasma proteins. This is achieved by control of the nature and location of the sulfonic acid substituents, in particular the sulfoalkyl groups. Also disclosed are pharmaceutical compositions and kits, as well as in vivo imaging methods.