Compound derived from Adenosine; ex vivo or in vivo method to increase the number of STEM and progenitor cells; kit to expand hematopoietic stem cells; the use of said Compound for expansion of Haematopoietic stem cells to treat inherited immunodeficiency disease, author You Immune and / or hematopoietic disorder (a divisional Application 2010 - 2009).

摘要

The present invention relates to compounds and compositions for expanding the number of CD34+ cells for transplantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.