IMIDAZOLINE 8-HEXYLOXYPHENYL-2-IMIDAZOLINE, 8-NONYLOXYPHENYL-2-IM IDAZOLINE AND 7-NONYLOXYPHENYL-2-IMIDAZOLINE AND 7-NONYLOXYPHENYL-2-IMIDAZOLINE AND OBTENTION PROCESS.

摘要

The present invention is related to the compounds 7-NONYLOXYPHENYL-2-IMIDAZOLINE AND 7-NONYLOXYPHENYL-2-IMIDAZOLINE and process for obtaining same. These compounds are obtained by a two-step process: an alkylation of 3ùhydroxybenzaldehyde with the corresponding alkyl halide obtaining 81% of isolated yield and a cyclization performed by ethylenediamine, potassium carbonate, triethylamine, iodine and t-butanol, obtaining quantitative yield. Both compounds, 7-NONYLOXYPHENYL-2-IMIDAZOLINE AND 7-NONYLOXYPHENYL-2-IMIDAZOLINE, have in vitro activity against Tripanosoma cruzi; the compounds have been evaluated over blood Trypomastigote from the NINOA and INC-5 strains, in the latter strain presenting an activity practically equal to the drugs of clinical use Nifortimox and Benznidazol at concentrations of 19.2 and 38.4 ÁM. The compounds 7-NONYLOXYPHENYL-2-IMIDAZOLINE AND 7-NONYLOXYPHENYL-2-IMIDAZOLINE, due to the chemical characteristics thereof could lead to molecular gels, which are formed by nanoparticles.