Bis (2,2-bitienylo)methane substituted - nucleobase and a method for its preparation, a layer of molecularly imprinted polymer and its method for making and using molecular imprinted polymer layers to detect and release of 5-fluorouracil

摘要

the subject invention is bis (2,2 '- bitienylo) methane, then the principle of nukleinowu0105 of general formula, in which r is adeninu0119, guaninu0119, cytozynu0119, tyminu0119 or uracil, and method of its production.in addition, the invention includes a layer of polymer and its manufacture molekularnie wdrukowanego way including the following stages, where (a) in a solution containing 5 - fluorouracil, bis (2,2 '- bitienylo) methane by the principle of nukleinowu0105 as functional monomer and monomer sieciuju0105cy arises kompl ex 5-fluorouracil with functional monomer.then (b) received compound 5-fluorouracil with functional monomer is subjected to electrochemical polymerization, whereby the bus electrode is deposited on a rigid layer, molekularnie wdrukowanego polymer with wdrukowanym 5-fluorouracil.subsequently, (c) wdrukowany 5 - fluorouracil wyekstrahowuje with this layer, resulting in a layer of molekularnie wdrukowanego polymer with molecular nieobsadzonymi wdrukowanymi gaps.the invention also includes the use of molekularnie wdrukowanego polymer detection and release of 5-fluorouracil, especially by impedimetrii pojemnou015bciowej or ru00f3u017cniczkowej woltamperometrii the pulse.