SYSTEM FOR EXSANGUINOUS METABOLIC SUPPORT OF AN ORGAN OR TISSUE

摘要

An exsanguinous metabolic support system for maintaining an organ or tissue ata near normal metabolic rate is disclosed. The system employs a warm perfusionsolution capable of supporting the metabolism of the organ or tissue therebypreserving its functional integrity. The system also monitors parameters ofthe circulating perfusion solution, such as pH, temperature, osmolarity, flowrate, vascular pressure and partial pressure of respiratory gases, andregulates them to insure that the organ is maintained under near-physiologicconditions. Use of the system for long-term maintenance of organs fortransplantation, for resuscitation and repair of organs having sustained warmischemic damage, as a pharmaceutical delivery system and prognosticator ofposttransplantation organ function is also disclosed.