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METHOD OF INDUCING DIFFERENTIATION OF BONE MARROW STROMAL CELLS TO NEURAL CELLS OR SKELETAL MUSCLE CELLS BY INTRODUCTION OF NOTCH GENE
METHOD OF INDUCING DIFFERENTIATION OF BONE MARROW STROMAL CELLS TO NEURAL CELLS OR SKELETAL MUSCLE CELLS BY INTRODUCTION OF NOTCH GENE
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机译:导入Notch基因诱导骨髓基质细胞向神经细胞或骨骼肌细胞分化的方法
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摘要
There is provided a method of inducingdifferentiation of bone marrow stromal cells to neuralcells or skeletal muscle cells by introduction of a Notchgene. Specifically, the invention provides a method ofinducing differentiation of bone marrow stromal cells toneural cells or skeletal muscle cells in vitro, whichmethod comprises introducing a Notch gene and/or a Notchsignaling related gene into the cells, wherein thefinally obtained differentiated cells are the result ofcell division of the bone marrow stromal cells into whichthe Notch gene and/or Notch signaling related gene havebeen introduced. The invention also provides a method ofinducing further differentiation of the differentiation-inducedneural cells to dopaminergic neurons oracetylcholinergic neurons. The invention yet furtherprovides a treatment method for neurodegenerative andskeletal muscle degenerative diseases which employsneural precursor cells, neural cells or skeletal musclecells produced by the method of the invention.
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