TOTAL SYNTHESIS AND IMMUNOLOGICAL EVALUATION OF SACCHARIDE MOIETIES OF THE LIPOPOLYSACCHARIDE FROM NEISSERIA MENINGITIDIS

摘要

The present invention relates to the total synthesis of the ±-GlcNAc-(1†’2)-±-Hep-(1†’3)-±-Hep-(1†’5)-±-Kdo core tetrasaccharide of the lipopolysaccharide from Neisseria meningitidis, the resulting product obtained by the total synthesis and ±-GlcNAc-(1†’2)-±-Hep-(1†’3)-±-Hep-(1†’5)-±-Kdo for use as a vaccine for immunization against diseases caused by infection with bacteria containing the tetrasaccharide, especially for immunization against meningitis, septicaemia, pneumonia and nasopharyngitis caused by Neisseria meningitidis.