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A NANOPARTICLE SUITABLE FOR DELIVERY OF A BIOMOLECULE INTO OR OUT OF A MEMBRANE ENCLOSED CELL OR CELL ORGANELLE
A NANOPARTICLE SUITABLE FOR DELIVERY OF A BIOMOLECULE INTO OR OUT OF A MEMBRANE ENCLOSED CELL OR CELL ORGANELLE
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机译:适于将生物分子送入或送出膜密闭的细胞或细胞器官的纳米颗粒
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摘要
A nano sized particle for in vitro or ex vivo biomolecule delivery to cell cultures through heat induced endosomal release comprising a superparamagnetic core coated in a heat sensitive coating, comprising membrane disruptive components and binding sites for attachment of biomolecules and markers to be delivered is provided. A method is provided for introducing the release effect of a plurality of said biomolecule and endosomal disrupture molecules by applying an alternating field to a cell culture harboring the particle described by the invention.
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