Method for Particle control of adefovir dipivoxil complex using polymeric additives and its application

摘要

PURPOSE: An adefovir dipivoxil polymeric complex, a use thereof, and a method for preparing the same are provided to improve flow property in a crystallization process by controlling crystalline and to increase efficiency and economic efficiency. CONSTITUTION: A method for changing physical chemical properties of adefovir dipivoxil co-crystal comprises a step of adding a polymeric additive to the adefovir dipivoxil co-crystal. The adefovir dipivoxil co-crystal includes adefovir dipivoxil suberic acid co-crystal and adefovir dipivoxil succinic acid co-crystal. The physical and chemical properties are the size, shape, and melting point of crystalline particle of adefovir dipivoxil. The adefovir dipivoxil suberic acid co-crystal and the adefovir dipivoxil succinic acid co-crystal are prepared by changing physical and chemical properties.