COMPOSITION FOR TREATING MALIGNANT PLEURAL MESOTHELIOMA COMPRISING POLYPHENOL COMPOUND EXTRACTED FROM GRAPE AND CHEMOTHERAPEUTIC CLOFARABINE

摘要

The present invention relates to a composition for treating malignant mesothelioma including a polyphenol-based compound extracted from grapes and an anticancer agent of clofarabine as active ingredients. More specifically, the present invention relates to a composition for treating malignant mesothelioma containing resveratol, a polyphenol-based compound of grapes and clofarabine, an anticancer agent as active ingredients. It is found that complex administration of resveratrol which is a polyphenol-based compound and an anticancer agent of clofarabine maintains minimum toxicity in normal mesothelial cells of Met-5A while inducing strong synergistic apoptosis in malignant mesothelioma cells of MSTO-211H, and it is proved that the synergistic toxic mechanism is carried out by a phenomenon of inducing apoptosis by inhibiting the activation of Nrf2, Sp1 and Akt, inducing the activation of p53, and changing the transcriptional activation of a regulatory gene at a molecular level. Resveratrol and clofarabine inhibits survivals of various cells and targets for malignant alteration and induces apoptosis, and therefore, can be effective as a novel agent for treating malignant mesothelioma.