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Gene signatures associated with the in vitro resistance to two tyrosine kinase inhibitors, nilotinib and imatinib
Gene signatures associated with the in vitro resistance to two tyrosine kinase inhibitors, nilotinib and imatinib
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机译:与两种酪氨酸激酶抑制剂尼罗替尼和伊马替尼的体外耐药性相关的基因特征
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摘要
PURPOSE: A gene having resistance against nilotinib and imatinib which are inhibitors of tyrosine kinase and a composition for diagnosing resistance against nilotibin are provided to be used for analyzing molecular status or screeing markers suitable for treating refractrory diseases towards TKI. CONSTITUTION: A composition for diagnosing resistance against nilotibin includes a gene having resistivity for imatinib and nilotibin as an active ingredient. The tyrosine kinase inhibitor is imatinib or nilotinib compound. The diagnosing method of resistance against nilotibin includes a step of confirming up-regulation of the gene. The diagnosing method against the tyrosine kinase inhibitor comprises a step of confirming up-regulation of the genes.
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