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Expanding Bone Marrow-Derived Immune Regulatory Cells and Immune Regulatory B cells by Activating GPCR19 Pathway In vivo or In vitro
Expanding Bone Marrow-Derived Immune Regulatory Cells and Immune Regulatory B cells by Activating GPCR19 Pathway In vivo or In vitro
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机译:通过激活GPCR19途径在体内或体外扩大骨髓衍生的免疫调节细胞和免疫调节B细胞
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摘要
PURPOSE: A method for screening a therapeutic agent for treating GPCR19(G-protein coupled receptor 19)-related diseases or a method for analyzing efficiency of a GPCR19 agonist is provided to obtain an anti-inflammatory pharmaceutical composition. CONSTITUTION: A method for screening a therapeutic agent for treating GPCR19-related diseases comprises: a step of administering a physiological activity control material to mammals exclusive of humans; a step of administering a GPCR19 agonist test material to the mammals; and a step of analyzing generation of regulatory B cells in the mammals. The test material is determined as a therapeutic agent for treating GPCR19-related diseases when cell production is increased over a control group.
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