Application of the tetrapeptide Pro-Gly-Pro-Val as a means of prevention and treatment of lipid metabolism disorders, a method of preventing and treatment of lipid metabolism disorders, pharmaceutical compositions for the prevention and treatment of lipid metabolism and PROCESS FOR ITS PREPARATION

摘要

1. Application of the tetrapeptide Pro-Gly-Pro-Val as a means of prevention and treatment of disorders of lipid obmena.2. A method for preventing and treating disorders of lipid metabolism, comprising intranasal administration of the drug based on the tetrapeptide Pro-Gly-Pro-Val in the effective kolichestve.3. A pharmaceutical composition for the prevention and treatment of lipid metabolism disorders, comprising a peptide having gipoholesterin and triglitseridemicheskim effect as active substance and auxiliary agent as a preservative, wherein the composition is suitable for intranasal administration, the peptide used as a peptide of general formula Pro- gly-Pro-Val.4. A composition according to claim 3, characterized in that it is formed as a solution with the following composition: Peptide Pro-Gly-Pro-Val - 1 ÷ 10 g / l; Nipagin - 0.9 ÷ 1.1 g / liter as preservative, distilled water - up to 1 litra.5. A process for preparing a pharmaceutical composition for the prevention and treatment of lipid metabolism disorders, comprising mixing the active substances and excipients, characterized in that as active substance the peptide use the general formula Pro-Gly-Pro-Val.6. A method according to claim 5, characterized in that the composition is prepared in the form of a solution with the following composition, suitable for nasal administration: Peptide Pro-Gly-Pro-Val - 1 ÷ 10 g / l; Nipagin - 0.9 ÷ 1.1 g / liter as preservative, distilled water - to 1 liter.