COMPOSITIONS CONTAINING NEISSERIA Meningitidis serogroup B AND C ANTIGENS, AND ADDITIONAL ANTIGEN

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention discloses an immunogenic composition having an immunogenic activity on serogroup B and C Neisseria meningitidis containing (a) N. meningitidis serogroup C (NmC) oligosaccharide, (b) proteoliposome vesicles of the outer membrane of N.meningitidis (NmB) serogroup B and (c) NmB protein containing and an amino acid sequence presented in the description, or an immunogenic fragment of the above sequence, or a sequence min. 80% identical to the above sequence. The ingredient (a) may be conjugated with a carrier, e.g. with a protein, CRM₁₉₇, a diphtherial anatoxin or a tetanus anatoxin. The immunogenic composition can contain aluminium hydroxide or MF59 as an adjuvant. What is described is a N.meningitidis serogroup B and C vaccine containing the described immunogenic composition.;EFFECT: using the invention enables preparing the combined vaccine eliciting an immune response on both serogroups of the agent.;6 cl, 4 dwg, 5 tbl, 6 ex