colorectal cancer prevention, and / or measurement of 5-amino salicylic acid drug efficacy by gene expression analysis in the treatment

摘要

A method is disclosed for the determination of 5-ASA efficacy in preventing and/or treating CRC in a mammalian, which comprises the analysis of the inhibition of the ²-catenin pathway in presence of 5-ASA. More in details, the method comprises measuring the expression of at least one gene involved in the regulation of the ²-catenin signalling pathway, such as µ-protocadherin, E-cadherin, ²-catenin, Axin1, ICAT, p21 waf-1 and the expression of onco-suppressor genes, such as KLF4 and CEBP±. Gene expression can be measured in accordance to the methods commonly available in the art such as QRT-PCR and immunohistochemistry.