Manufacturing methods and diethylenetriaminepentaacetic acid derivative of diethylenetriaminepentaacetic acid derivative

摘要

A method for producing simply and efficiently intermediate compounds for the synthesis of gadolinium complex of substituents for improving the organ specificity and retention in blood has been introduced, the present invention was prepared by the method and an object thereof is to provide a synthetic intermediate. Step to remove excess allyl halide compound; reacting the allyl halide compound pentaacetic acid pentaester diethylenetriamine manufacturing method pentaacetic acid derivative diethylenetriamine according to the present invention (I) are and, solvent, diethylenetriaminepentaacetic acid and comprising a step of reacting a base with the reaction product of an allyl halide compound and penta esters._Wherein, R 1 _{~R 5} is a _{C 1-6} alkyl group independently]