How to increase the successful of the Japanese encephalitis virus antigen by micro-needle device and a micro-needle device

摘要

Provided is a method for enhancing immunogenicity by using a microneedle device which is capable of enhancing the immunogenicity of a Japanese encephalitis virus antigen. The above-described method for enhancing immunogenicity by using a microneedle device comprises transdermally administering a Japanese encephalitis virus antigen by using a microneedle coated with the Japanese encephalitis virus antigen that is an antigen originating in monkey kidney cells (Vero cells).  Thus, antibody against the Japanese encephalitis virus antigen is effectively elevated.  After transdermally administering the microneedle coated with the Japanese encephalitis virus antigen, a patch containing lauryl alcohol is further applied.