SILVER NANOCLUSTER PROBE AND TARGET POLYNUCLEOTIDE DETECTION METHOD USING SAME, AND SILVER NANOCLUSTER PROBE DESIGN METHOD

摘要

The present invention provides a silver nanocluster probe which comprises a silver nanoparticle binding region and a specific nucleotide sequence region that specifically binds to a target polynucleotide, wherein the silver nanocluster probe is configured such that it will emit detectable light when silver nanoparticles bind to the silver nanoparticle binding region to form a silver nanocluster, but light emission from the silver nanocluster probe will decrease or decay when the target polynucleotide binds to the specific nucleotide sequence region. According to the present invention, either the presence of a target polynucleotide in a sample or a mutation in the target polynucleotide can be detected in a rapid and convenient manner by determining whether light emission decreases or decays when the target polynucleotide binds to the specific nucleotide sequence region of the silver nanocluster probe that emits detectable light.