EVOKING PROTECTION AGAINST STREPTOTOCCUS PNEUMONIAE INCORPORATING B-CELL AND T-CELL PNEUMOCOCCAL PROTEIN ANTIGENS AND PNEUMOCOCCAL POLYSACCHARIDES DELIVERED CONCOMITANTLY

摘要

This disclosure is directed to compositions that combine the polysaccharide-specific antibody protection afforded by the conventional vaccines through carrier effects provided by one or more pneumococcal common T-cell antigen(s) together with Streptococcus pneumoniae-specific Th-17 responses elicited by the pneumococcal carrier common T-cell antigen. The disclosed compositions are useful for pan-serotypic protection against NP carriage, and antibody responses against common pneumococcal virulence factors, potentially useful for pan-serotype protection against Streptococcus pneumoniae invasive diseases.