首页>
外国专利>
Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours
Dendritic high-molecular-weight polymer drug carriers and their conjugates with drugs especially for treatment of solid tumours
展开▼
机译:树突状高分子聚合物药物载体及其与药物的结合物,特别是用于治疗实体瘤的药物
展开▼
页面导航
摘要
著录项
相似文献
摘要
The present invention relates to water-soluble high-molecular-weight polymer drug carriers and their conjugates with drugs, derived from dendrimers of the amidoamine and 2,2-bis(hydroxymethyl)propanoic types, the amino and hydroxy end groups of which are attached to semitelechelic copolymers of N-(2 hydroxypropyl)methacrylamide (HPMA) through biodegradable spacers. The polymer carriers and conjugates enable targeted transport notably of anticancer drugs into solid tumors in which biodegradation, the associated controlled drug release and subsequent elimination of polymer carrier from the organism are provided. The polymer carrier conjugated with a cancerostatic for use in targeted therapy of human tumors.
展开▼