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Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species
Short peptides useful for treatment of ischemia/reperfusion injury and other tissue damage conditions associated with nitric oxide and its reactive species
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机译:短肽可用于治疗与一氧化氮及其反应性物种有关的缺血/再灌注损伤和其他组织损伤
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摘要
This invention discloses isolated short peptides comprising the amino acid sequence Cys-Glu-Phe-His (CEFH; SEQ ID NOS: 1 and 15) and analogs thereof as well as compositions comprising CEFH peptides and analogs thereof. The CEFH peptides disclosed herein are effective in mediating the denitration of 3-nitrotyrosines (3-NT) in cellular proteins thereby preventing tissue damage associated with excess nitric oxide (NO) and its reactive species. The CEFH peptides disclosed herein are useful in the treatment of ischemia/reperfusion (I/R) injury and other disorders.
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机译:本发明公开了包含氨基酸序列Cys-Glu-Phe-His(CEFH; SEQ ID NOS:1和15)及其类似物的分离的短肽,以及包含CEFH肽及其类似物的组合物。本文公开的CEFH肽可有效介导细胞蛋白中3-硝基酪氨酸(3-NT)的脱硝,从而防止与过量一氧化氮(NO)及其反应性物种相关的组织损伤。本文公开的CEFH肽可用于治疗缺血/再灌注(I / R)损伤和其他疾病。
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