A method for treating rheumatoid arthritis in a Subject that has been previously treated with methotrexate, leflunomide, sulfasalazine and / or Hydroxychloroquine, which comprises administering to the subject an effective amount of sarilumab; and Pharmaceutical composition comprising sarilumab and a member of the Grup Or what is methotrexate, leflunomide, sulfasalazine and Hydroxychloroquine.

摘要

The present invention provides compositions and methods of treating and improving the symptoms of rheumatoid arthritis using an antibody or antigen-binding fragment thereof that specifically binds human interleukin-6 receptor (hIL-6R) with a DMARD.