Compounds derived from indole and indazol that Activate AMPK; Pharmaceutical composition that comprises; and use for treating or Preventing chronic kidney disease, diabetic nephropathy, diabetes, among other diseases.

摘要

A device and process for vacuum pyrolysis of shredded scrap material, such as tires, to produce a pyrolytic oil from which valuable terpenes, such as limonene and pulegone, may be extracted and purified, wherein the device includes a pyrolysis chamber, a chiller, a first distillation column (43), a second distillation column (59) to recover the terpenes and terpenoids from the pyrolytic oils. The two columns are used at two pressures, atmospheric pressure and reduced pressure (hard vacuum). The vapours from the first distillation column are condensed by flowing through a small orifice (53) (Joule-Thomson process). The obtained product mixture comprising terpenes and terpenoids may be irradiated by a broad spectrum ultraviolet lamp so that the concentration of some terpenes, such as isopulegol, increases while other materials, such as toluene, decreases.