Chromane derivatives substituted Compounds, modulators of Calcium Sensing receptor (CaSR); processes for preparing them and Pharmaceutical Composition and its use to treat, manage and / or reduce diseases such as hyperthyroidism, chronic renal failure, hyperkalemia, Hyper parathyroid adenoma. Phosphatemia and diarrhea, among others.

摘要

The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.