3.4 - dihidroisoquinolina substituted Compounds, inhibitors of PRMT5 Kit; pharmacist; Pharmaceutical Composition and method of inhibiting PRMT5 method to treat; gene expression; method to alter the transcription; method of treatment of a disorder, such as cancer, diabetes Teas and obesisdad, among others.

摘要

Described herein are compounds of Formula (), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity. Methods of using the compounds for treating PRMT5-mediated disorders are also described.