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Salophene iron complexes with heterocyclic N-donor ligands, process of their preparation and their use as medicaments in antitumor therapy

机译:具有杂环N-给体配体的红氮铁配合物,其制备方法及其在抗肿瘤治疗中的药物用途

摘要

ufeffkomplexnu00ed compounds of iron in the oxidation degrees + ii and + iii, salophenem {2,2u00b4 - ((1e, 1u00b4e) - (1,2 - fenylenbis (azanylyliden)) bis (methanylyliden) difenolu00e1tor (2 -) ligand} and complementary n - donorovu00fdmi heterocyklicku00fdmi ligands and their krystalosolvu00e1ty, expressed by the formula i and ii where x.sub.1.n. - x.sub.4.n.is any combination of n methanylylidenovu00fdch groups and (4 - (n) azanylylidenovu00fdch groups, where n can take values 1 or 2, r1 - r8 represents a hydrogen atom, alkyl, substituted alkyl, aryl, substituted aryl, alkenyl, hydroxy and amino group.method of preparation of these compounds, the detergent for use in medicine and the use of pharmacological means as medicines for the treatment of cancer.
机译:氧化度为+ ii和+ iii的铁的化合物,Salophenem {2,2 (-(1e,1 u00b4e)-(1,2-苯烯基(azanylyliden)))bis(methanylyliden)difenol 由式(i)和式(ii)表示的互补的n-供体(2-)配体}和互补的n-供体ov uffmi异环蛋白 u00fdmi配体及其krystalosolv u00e1ty。 n个甲炔基利诺夫基团和(4-(n)氮杂基利得诺夫基团)的任意组合,其中n可以取值1或2,r1-r8代表氢原子,烷基,取代的烷基,芳基,取代的芳基,烯基,羟基这些化合物的制备方法,用于医学的去污剂和用作治疗癌症的药物的药理学手段的用途。

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