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Recombinant bacteriophage peptide library and its use for identifying a peptide or a polypeptide which has an intermolecular interaction with a target of interest
Recombinant bacteriophage peptide library and its use for identifying a peptide or a polypeptide which has an intermolecular interaction with a target of interest
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机译:重组噬菌体肽文库及其在鉴定与目标靶标具有分子间相互作用的肽或多肽中的用途
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摘要
This invention provides, in one embodiment, a recombinant virus or a recombinant virus library wherein each virus comprises a protein involved in viral attachment or infection, a polypeptide which differs by at least a single amino acid from another peptide or polypeptide in the library, and a modified cleavage site that is proximal to the peptide and the protein, wherein the cleavage site is modified such that a compound mediating cleavage has a reduced binding affinity for it as compared to a non-modified cleavage site. The invention further provides a target of interest complex comprising a protease, a target of interest involved in an intermolecular interaction, and a flexible linker that attaches the protease and target of interest. The invention further provides uses thereof, including a method for identifying a peptide which has an intermolecular interaction with a target of interest or identifying the agonistic or antagonistic feature of a peptide that has an intermolecular reaction with a target of interest.
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