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Nucleic acid molecule encoding a substantially non-toxic mutein of clostridium perfringens alpha-toxin and attenuated clostridium perfringens organisms comprising said nucleic acid
Nucleic acid molecule encoding a substantially non-toxic mutein of clostridium perfringens alpha-toxin and attenuated clostridium perfringens organisms comprising said nucleic acid
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机译:编码基本上无毒的产气荚膜梭菌α毒素的突变蛋白和减毒的产气荚膜梭菌生物的核酸分子
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摘要
The present invention discloses attenuated Clostridium perfringens organisms that express a substantially nontoxic alpha -toxin. The expressed alpha -toxin is a deletion mutein that relative to the alpha -toxin of the mature alpha -toxin of Clostridium perfringens strain 13, is missing at least nine consecutive amino acid residues including His 68 . The present invention also discloses attenuated organisms that encode the muteins, as well as the use of such attenuated organisms as vaccines.
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